» Drug Encapsulation
» Solubility Enhancement
» Solid Dispersion
» Surface Modification
» Release Profile Testing
Solid dispersion is a relatively simple and effective way to improve the dissolution rate and bioavailability of poorly soluble API's in orally administered formulations. Typically, a solid dispersion consists of a hydrophilic polymer matrix and a hydrophobic drug. The poorly soluble drug is dispersed in the water soluble polymer molecularly, as amorphous or crystalline particles. Depending on specific formulations, the following can happen in a solid dispersion formulation:
Solid dispersion can be prepared by melt of solvent methods. In the melt method, an insoluble drug and a water soluble polymer are heated together until melted. Solvent method involves co-dissolving the drug and polymer in a common solvent followed by removing the solvent by spray drying or lyophillization.
At Phosphorex, our experienced scientists can help you design your solid dispersion system based on the nature of your insoluble drug compound. We can prepare a solid dispersion formulation for proof of concept with a minimum amount of your precious compound and provide analytical data.
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