The surface properties of drug encapsulated microspheres and nanoparticles are very important parameters. Whether it is for cell entry or targeted drug delivery, the chemical nature of the particle surface plays a critical role. We provide solutions for surface modification, coating and conjugation to help our customers achieve specific surface properties for their applications.
We can vary the surface of your drug loaded Degradex® PLGA particles so they are neutral, positively or negatively charged. We can also put functional groups such as amine or carboxyl groups on the particle surface to allow chemical attachment of biomolecules. PEGylation is a process to add polyethylene glycol units onto the surface of microparticles and nanoparticles, which can help extend the circulation time in intravenously administrated particle formulations.
A chemical entity such as protein, surfactant and adjuvant can be coated via physical absorption onto the surface of microspheres and nanoparticles which may enable BBB (blood-brain barrier) crossing, cell entry and targeting.
A biomolecule such as peptide, antibody, and growth factor can be attached via covalent bonding to the surface of microspheres and nanoparticles for targeted drug delivery. This is typically done via COOH/EDC or amine/aldehyde chemistry.
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