With 15 years of experience in formulating biodegradable microspheres and other sustained release modalities, Phosphorex offers tailored solutions to optimize a drug’s release and long-acting profile to achieve the desired therapeutic effect, reduce side effects and enhance patient compliance.
Encapsulating drug molecules, whether small molecules, peptides or proteins, into microspheres of biodegradable polymers can deliver a number of benefits including:
- Sustained release
- Protection of an unstable API
- Reduction of side effects
- Extension of patent life
- Improved patient compliance
There are many approved microsphere-based “depot” products in the marketplace, accounting for billions of dollars of annual sales. Most are based on biodegradable poly(lactide-co-glycolide) (PLGA) microspheres and are administered subcutaneously or intramuscularly with a dosing frequency from once a week to once every several months.
In addition to PLGA, other biodegradable polymers such as polylactide (PLA), polycaprolactone (PCL), polyanhydrides and poly(ortho esters) may also be used as microsphere matrix materials. The release profile of a microsphere product can be controlled by choosing different types of polymers or varying the lactide/glycolide (L/G) ratio in the PLGA polymer.
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