Conventional systems of drug delivery involve repeated, separate dosages of a drug over a certain period of time. This method, while effective, involves return trips to doctor’s offices and hospitals, remembering to take medication frequently, and fluctuations in the drug concentration in an individual’s system, among other drawbacks. For certain drugs, a more advantageous and effective system involves less frequent administrations, and a more constant and continuous level of drug concentration. Researchers worldwide are now developing these sustained release systems for drug delivery. These systems involve injecting or otherwise inserting a drug into the body at one or more infrequent points in time, where it would be slowly released in a controlled manner from its formulation. One of the methods being used to achieve this sustained release goal is microencapsulation, in which the drug in question is encapsulated in a polymer-based microsphere. This enables the kind of slow controlled release desired; as the microsphere degrades, the drug is released.
Microencapsulation is already being used in multiple drug formulations to produce a sustained release system. Further posts will explore in more detail the method and potential of these examples. Phosphorex offers microencapsulation services that can achieve desired sustained release systems. We can work with clients to develop compatible drug formulations with a variety of polymer microspheres.