An application in which nanoparticles are successful is ocular drug delivery. In order to treat certain ocular diseases, it is necessary that the therapeutic agent penetrates the cornea. If this cannot be achieved through a dropwise formulation, one of three options must be explored. First, the drug can be introduced systemically in very large doses in hopes of penetrating the blood – ocular tissue barrier. Options two and three are to either inject the drug intravitreally or to utilize intravitreal implants. None of these options are ideal, though, because they are potentially dangerous and, in the cases of the injection and the implant, are invasive and require skilled application.
Use of polymeric nanoparticles solves these issues. The small size of nanoparticles prevents the eye from recognizing them as a foreign object, allowing them to circulate within the eye for an extended period of time without being cleared, thus increasing their likelihood of penetrating the cornea. Furthermore, when used in a lyophilic colloidal formulation, nanoparticles can carry poorly water soluble drugs via a dropwise formulation. This formulation is easy for the patient to administer themselves and it provides a significantly increased drug bioavailability.
By using polymeric nanoparticles for ocular drug delivery, the discomfort and inconvenience associated with other methods is eliminated while overall drug efficacy is increased.
Chitosan is the most commonly used polymer for this application because it is biocompatible and has superior bioadhesion. At Phosphorex, we can manufacture several different types of nanoparticles, including those made from chitosan upon special request. For all inquiries, please call (508) 435-9100 (toll free at (877) 288-8010) or send an email to firstname.lastname@example.org. Our technical support department is happy to work with you.