Bacteria below the gum line of teeth are the main cause of periodontal gum disease; an affliction that results in bad breath, tender or painful gums, swollen and bleeding gums, pockets along the sides of teeth, loose and shifting teeth, and ultimately tooth loss. While a technique known as scaling and root planning (SRP) can help remove much of the bacteria that is causing the infections, oftentimes the bacteria is too far down into the gums to be accessed. A long-lasting treatment that continues to kill bacteria even after dentist’s visits, thus giving the gums an opportunity to heal, is invaluable for any person suffering from periodontitis.
ARESTIN® is a formulation comprised of PLGA microspheres containing the synthetic tetracycline antibiotic minocycline hydrochloride. It is a sustained release product that is administered subgingivally into the pockets created by the gum disease following scaling and root planning. Upon administration, the slow release of the antibiotic from the microspheres provides a continuous method of killing off any bacteria found in the deep reserves of the periodontitis pockets, making sure no further bacteria grow there. This enables the gums to heal and removes the need for multiple trips to the dentist for continued treatment.
The microspheres and microencapsulation services offered at Phosphorex can aid in achieving the benefits of continuous sustained release formulations of other drugs and compounds.