Lipid Nanoparticles (LNPs) for Nucleic Acid Delivery
With Lipid Nanoparticles (LNPs) at the forefront of medical innovation, Phosphorex understands that this groundbreaking technology is poised to revolutionize therapeutic nucleic acid delivery and shape the future of medicine.
With the commercial success of pioneering therapies like ONPATTRO®, COMIRNATY®, and SPIKEVAX®, the potential applications of LNPs have been validated and expanded. The market is now eager to witness the next generation of LNPs, unlocking even greater possibilities for delivering nucleic acids to extra-hepatic tissues and achieving cell-specific targeting.
For LNPs, our team at Phosphorex has years of experience in the following:
- Lipid Library Screening
- Formulation Optimization
- Scale-up and Process Development
- Batch Manufacture for IND Enabling Studies
- GMP Manufacturing to Support Phase 1/2 Clinical Studies (coming late 2024)
What sets us apart from other CDMOs and why should you work with us?
- Access to Proprietary Ionizable Lipids
- Multiple Mixing Technologies (in-house) including Microfluidics from Precision Nanosystems Inc and Unchained Labs (previously Particle Works), T-mixers, and Impingement Jet Mixers
- Extensive Expertise in Down-stream Processing including Tangential Flow Filtration (TFF)
- Comprehensive and Stage-appropriate Analytical Capabilities
- Flexible Team of Experts to Support Formulation Screening, Lead Candidate Selection, Scale-up for IND-enabling studies, and Clinical Manufacturing (Q3 2024)
Analytical Capabilities:
Formulation, process development, and analytics are interconnected. Advancing analytical method development in a stage appropriate manner is critical to ensure success of program from feasibility to clinical manufacture. Phosphorex’s analytical services for sustained release drug delivery systems include API characterization, physical characterization, and development stability studies.
Choose us for our unique access to proprietary ionizable lipids, diverse in-house mixing technologies, extensive downstream processing expertise, comprehensive analytical capabilities, and a flexible team of experts. Partner with us to unlock the full potential of LNPs and propel your therapeutic nucleic acid delivery to new heights. For more information on our LNP capabilities, email us bd@phosphorex.com.