Did you know that shaking or vortexing mRNA-lipid nanoparticles (LNPs) can compromise their integrity? A recent study, "Don’t shake it! Mechanical stress testing of mRNA-lipid nanoparticles", led by Andrea Allmendinger from the University of Freiburg, Germany, reveals that mechanical stress during handling and transport can lead to larger particle sizes, reduced nucleic acid encapsulation, and a decrease in the overall stability of these formulations.
Key Findings:
When it comes to mRNA-lipid nanoparticles (LNPs), the more mRNA they carry doesn’t always mean better delivery. A recent study, "Transfection Potency of Lipid Nanoparticles Containing mRNA Depends on Relative Loading Levels," led by Pieter R. Cullis and Anna K. Blakney from the University of British Columbia, Canada, reveals an intriguing paradox—LNPs with higher mRNA loading levels actually show lower transfection efficiency, both in vitro and in vivo.
Key Findings:
Contract Pharma | Pharma Matters Q&A interview with our CEO, Jarlath Keating
A conversation with Jarlath Keating, CEO of Phosphorex, on the future of LNPs in pharmaceutical innovation.
In recent years, lipid nanoparticles (LNPs) have emerged as a groundbreaking technology in the pharmaceutical world, revolutionizing the delivery of complex therapeutic molecules like RNA and DNA.
Omni Boston Hotel at the Seaport
The State of Possible Conference is the premier event for the Massachusetts life sciences industry. Over the course of the day, attendees from the lab to the C-suite are exposed to engaging panel discussions and informative keynotes on what’s next in both the science and business of biopharma. The event program covers the Massachusetts life sciences ecosystem, as well as a forward-looking view on how Massachusetts will retain its position of global leadership.
The 4th LNP Formulation & Process Development Summit returns to Boston, as the only industry summit dedicated to unveiling the hottest pre-clinical and clinical data, overcoming the greatest challenges within the LNP IP space and uncovering the most innovative LNP formulations for extrahepatic delivery of cell therapies, gene therapies, mRNA therapeutics and beyond!
Join ASGCT in New Orleans, May 13-17, 2025 for the premier event in cell and gene therapy, the ASGCT 28th Annual Meeting!
The BIO International Convention is the largest and most comprehensive event for biotechnology, representing the full ecosystem of biotech with 20,000 industry leaders from across the globe.
Whether you work at a public pharmaceutical company, biotech startup, academia, non-profits, and government or are a researcher, business development professional or investor, BIO is where you'll make valuable connections and build relationships. Our proprietary BIO One-on-One Partnering™ match-making platform—included in the Premier Access registration package—allows you to find potential partners, schedule and accept meetings.
Uniting North American biopharma decision-makers to innovate at speed, equipping them with the critical intelligence & partners they require to make informed pipeline decisions in early-stage R&D.
Covering Cutting-Edge Scientific and Business Trends in Drug Delivery
Pharma, biotech and drug delivery industries gathered at the 14th annual PODD event to assess delivery needs, information on deals and and latest trends in innovative drug delivery technologies. This included small molecules, biologics, combination products, connected devices, cell and gene delivery and more.
PODD provided partnering opportunities through organized networking for new, emerging and established collaborations.
Discovery and Basic Research
Basic research advances fundamental knowledge and predictions that form the scientific foundation for progress in applied science. Discovery research leads to new scientific ideas, theories, applications, and ways of thinking that form the basis of growth and development in different fields. Generating this critical knowledge is the first step toward inventing new tools, sparking therapeutic innovation, and enabling a more rapid and successful delivery of novel drugs to the market.
Press Announcement: Phosphorex and NOF Corporation launches Innovation and Training Center in Hopkington, MA....