Advancing Nanomedicines from Formulation to Scale-Up to Clinical Supply.
At Phosphorex, we offer a range of innovative solutions for the delivery of nucleic acids, facilitating cellular entry and endosome escape including liposomes, lipid nanoparticles, and cationic polymers.
Our team accelerates the development of nanomedicines by fabricating nanoparticles, modifying their surface for different targeting needs, scaling up to support preclinical and IND-enabling studies and developing GMP processes.
Our team of experts offer tailored solutions to optimize a drug's release and long-acting profile to achieve the desired therapeutic effect, reduce side effects and enhance patient compliance.
Repeated dosing of mRNA-based lipid nanoparticles (LNPs) is often hindered by the immune system’s response to PEGylated lipids. A recent study, "High-Density Brush-Shaped Polymer Lipids Reduce Anti-PEG Antibody Binding for Repeated Administration of mRNA Therapeutics," by Daniel J. Siegwart and his team at UT Southwestern Medical Center, USA, introduces a breakthrough strategy to enhance LNP performance.
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Inside Phosphorex: Our Culture, Our Mission
At Phosphorex, innovation isn’t just what we do—it’s who we are. Our team is driven by a shared passion for advancing drug delivery solutions, pushing the boundaries of lipid-based therapeutics, and making a real impact on patient lives.
Our latest Corporate Culture Video gives you a behind-the-scenes look at what makes Phosphorex a leader in the field—our collaborative spirit, scientific expertise, and commitment to excellence.
Curious to see what drives us? Watch now and get to know the people, values, and mission that shape Phosphorex every day.
Click here to view video:https://youtu.be/Eq77ZpxPXRI
Did you know that shaking or vortexing mRNA-lipid nanoparticles (LNPs) can compromise their integrity? A recent study, "Don’t shake it! Mechanical stress testing of mRNA-lipid nanoparticles", led by Andrea Allmendinger from the University of Freiburg, Germany, reveals that mechanical stress during handling and transport can lead to larger particle sizes, reduced nucleic acid encapsulation, and a decrease in the overall stability of these formulations.
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Press Announcement: Phosphorex and NOF Corporation launches Innovation and Training Center in Hopkington, MA....
Phosphorex leverages its expertise in particle-based formulations to address the challenges associated with therapeutic agent delivery. We understand the need for specific tissue or cell targeting to maximize therapeutic effects, especially in cases where current modalities lack such capabilities. Read more
We have worked with numerous advanced drug payload types designed to revolutionize delivery in various therapeutic areas. We support tailored solutions to address specific application needs in the following modalities
Our experience spans a range of payloads suited to a variety of applications and research needs. Our team is committed to providing the highest quality standard of services to our clients with efficacy, stability, and safety as our top priority.
We have been working with Phosphorex for about 3 years developing particulate delivery systems for both small molecule and gene based therapeutics to treat retinal degeneration. We are a small company, so in addition to the very challenging technical issues, there were resource constraints and aggressive timelines. Despite those challenges Phosphorex delivered for us...and in a very collegial way....awesome group of folks to work with.
Our specialized team is dedicated to supporting innovative drug delivery solutions that enhance the efficacy and safety of a wide range of therapeutics. We are committed to advancing the field of drug delivery, ensuring optimal outcomes for patients and maximizing the potential of your therapies.
With 20 years of experience for particle-based formulation and development, we are committed to ensuring our client's success every step of the way, from proof of concept to clinical studies. We are excited to offer cGMP capabilities in 2025.
Phosphorex is a CDMO specializing in innovative and proven particle-based drug delivery solutions. Our two-decade of experience, fortified with skilled and dedicated employees (scientists), yields trusted and collaborative Pharma & Biotech partnerships.
Our leadership team is comprised of experienced and dedicated individuals who are committed to ensuring the success of our organization.
We are excited that you're considering joining our team. Our employees are our greatest assets, and we are committed to offering a supportive and collaborative work environment.